For a complete list see pubmed

Häußler, D., D. Manevski, J. Frädrich, V. Brunner, O. Prokopchuk, A. Sommer, B. Toledo, P. Knolle, M.E. Martignoni, H. Friess, P. Waterhouse, A. Krüger. 2025. Extent of N-glycosylation of the metalloproteinase inhibitor and cytokine TIMP-1 determines pancreatic cancer cell proliferation and survival via CD63. J Biol Chem 301:110211. doi: 10.1016/j.jbc.2025.110211

Bayerl, F., P. Meiser, S. Donakonda, A. Hirschberger, S.B. Lacher, A.M. Pedde, C.D. Hermann, A. Elewaut, M. Knolle, L. Ramsauer, T.J. Rudolph, S. Grassmann, R. Öllinger, N. Kirchhammer, M. Trefny, M. Anton, D. Wohlleber, B. Höchst, A. Zaremba, A. Krüger, R. Rad , A.C. Obenauf, D. Schadendorf, A. Zippelius, V.R. Buchholz, B.U. Schraml, J.P. Böttcher. 2023. Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses. Immunity  56:1341-1358.e11. doi: 10.1016/j.immuni.2023.05.011

Eckfeld, C., B. Schoeps, D. Häußler, J. Frädrich, F. Bayerl, J.P. Böttcher, P. Knolle, S. Heisz, O. Prokopchuk, H. Hauner, E. Munkhbaatar, I.E. Demir, C.D. Hermann, A. Krüger. 2023. TIMP-1 is a novel ligand of Amyloid Precursor Protein and triggers a pro-inflammatory phenotype in human monocytes. J Cell Biol 222 : e202206095, 2023 doi: 10.1083/jcb.202206095

Schoeps, B., J. Frädrich, A. Krüger. Cut loose TIMP-1: an emerging cytokine in inflammation.  Trends Cell Biol 33 : 413-426, 2023 doi: 10.1016/j.tcb.2022.08.005

Bolik, J., F. Krause, M. Stevanovic, M. Gandraß, I. Thomsen, S. Schacht, E. Rieser, M. Müller, N. Schuhmacher, J. Fritsch, R. Wichert, E. Galun, J. Bergmann, C. Röder, C. Schafmayer, J.H. Egberts, C. Becker-Pauly, P. Saftig, R. Lucius, W. Schneider-Brachert, R. Barikbin, D. Adam, M. Voss, W. Hitzl, A. Krüger, B. Strilic, I. Sagi, H. Walczak, S. Rose-John, D. Schmidt-Arras. 2022. Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis. J Exp Med 219 : e20201039, 2022 doi: 10.1084/jem.20201039

Prokopchuk O., Hermann C.D., Schoeps B., Nitsche U., Prokopchuk OL., Knolle P., Friess H., Martignoni M.E., A. Krüger. 2021. A novel tissue inhibitor of metalloproteinases-1/liver/cachexia score predicts prognosis of gastrointestinal cancer patients. J Cachexia Sarcopenia Muscle 12 : 378-392, 2021. doi: 10.1002/jcsm.12680.

Hermann, C.D., B. Schoeps, C. Eckfeld, E. Munkhbaatar, L. Kniep, O. Prokopchuk, N. Wirges, K. Steiger, D. Häußler, P. Knolle, E. Poulton, R. Khokha, B.T. Grünwald, I.E. Demir, A. Krüger. TIMP1 expression underlies sex-disparity in liver metastasis and survival in pancreatic cancer. J Exp Med 218 : e20210911, 2021. doi: 10.1084/jem.20210911

Schoeps, B., C. Eckfeld, L. Flüter, S. Keppler, R. Mishra, P. Knolle, F. Bayerl, J. Böttcher, C.D. Hermann, D. Häußler, A. Krüger. Identification of invariant chain CD74 as a functional receptor of tissue inhibitor of metalloproteinases-1 (TIMP-1). J Biol Chem 297 : 101072, 2021. doi: 10.1016/j.jbc.2021.101072

Schoeps, B., C. Eckfeld, O. Prokopchuk, J.P. Böttcher, D. Häußler, K. Steiger, I.E. Demir, P. Knolle, O. Soehnlein, D.E. Jenne, C.D. Hermann, A. Krüger. TIMP1 triggers neutrophil extracellular trap formation in pancreatic cancer. Cancer Res 81 : 3568-3579, 2021.  doi: 10.1158/0008-5472.CAN-20-4125

Morigny, P., D. Kaltenecker, J. Zuber, J. Machado, L. Mehr, F.F. Tsokanos, H. Kuzi, C.D. Hermann, M. Voelkl, G. Monogarov, C. Springfield, V. Laurent, B. Engelmann, H. Friess, I. Zörnig, A. Krüger, J. Krijgsveld, O. Prokopchuk, S. Fisker Schmidt, M. Rohm, S. Herzig, M. Berriel Diaz. Association of circulating PLA2G7 levels with cancer cachexia and assessment of darapladib as a therapy. J Cachexia Sarcopenia Muscle 12 : 1333-1351, 2021 doi: 10.1002/jcsm.12758

Mohan, V., J.P. Gaffney, I. Solomonov, M. Levin, M. Klepfish, S. Akbareian, B. Grünwald, O. Dim, M. Eisenstein, K.H. Yu, D.P. Kelsen, A. Krüger, D. Edwards, I. Sagi. Conformation-specific inhibitory anti-MMP-7 monoclonal antibody sensitizes pancreatic ductal adenocarcinoma cells to chemotherapeutic cell kill. Cancers 13 : 1679, 2021 doi: 10.3390/cancers13071679

Zhao, Y., B. Schoeps, D. Yao, Z. Zhang, K. Schuck, V. Tissen, C. Jäger, A.M. Schlitter, R. van der Kammen, C. Ludwig, J.G. D’Haese, S. Raulefs, N. Maeritz, S. Shen, X. Zou, A. Krüger, J. Kleef, C.W. Michalski, H. Friess, M. Innocenti, B. Kong. mTORC1 and mTORC2 converge on the Arp2/3 complex to promote KrasG12D-induced acinar-to-ductal metaplasia and early pancreatic carcinogenesis. Gastroenterology 156 : 1755-1770, 2021 doi: 10.1053/j.gastro.2020.12.061

Eckfeld, C., D. Häußler, B. Schoeps, C.D. Hermann, A. Krüger. Functional disparities within the TIMP family in cancer: hints from molecular divergence.  Cancer Metastasis Rev 38 : 469-481, 2019. doi: 10.1007/s10555-019-09812-6

Grünwald, B., B. Schoeps, A. Krüger. Recognizing the molecular multifunctionality and interactome of TIMP-1. Trends Cell Biol 29 : 6-19, 2019. doi: 10.1016/j.tcb.2018.08.006

Görgülü, K., K.N. Diakopoulos, J. Ai, B. Schoeps, D. Kabacaoglu, A.F. Karpathaki, K.J. Ciecielski, E. Kaya-Aksoy, D.A. Ruess, A. Berninger, M. Kowalska, M. Stevanovic, S.M. Wörmann, T. Wartmann, Y. Zhao, W. Halangk, S. Voronina, A. Tepikin, A.M. Schlitter, K. Steiger, A. Artati, J. Adamski, M. Aichler, A. Walch, M. Jastroch, G. Hartleben, C.S. Mantzoros, W. Weichert, R.M. Schmid, S. Herzig, A. Krüger, B. Sainz Jr., M. Lesina, H. Algül. Levels of the autophagy related 5 protein affect progression and metastasis of pancreatic tumors in mice. Gastroenterology 156 : 203-217, 2019. doi: 10.1053/j.gastro.2018.09.053

Prokopchuk O., Grünwald B., Nitsche U., Jäger C., Prokopchuk OL., Schubert EC, Friess H, Martignoni ME, A. Krüger. Elevated systemic levels of the matrix metalloproteinase inhibitor TIMP-1 correlate with clinical markers of cachexia in patients with chronic pancreatitis and pancreatic cancer. BMC Cancer 18 : 128. 2018. doi: 10.1186/s12885-018-4055-9.

Grünwald, B., V. Harant, S. Schaten, M. Frühschütz, R. Spallek, B. Hoechst, K. Stutzer, S. Berchtold, M. Erkan, O. Prokopchuk, M. Martignoni, I. Esposito, M. Heikenwaelder, A. Gupta, J. Siveke, P. Saftig, P.A. Knolle, D. Wohlleber, A. Krüger, Pancreatic pre-malignant lesions secrete TIMP1, which activates hepatic stellate cells via CD63 signaling to create a pre-metastatic niche in the liver. Gastroenterology 151 : 1011-1024, 2016. doi: 10.1053/j.gastro.2016.07.043

Seubert, B., B. Grünwald, J. Kobuch, H. Cui, F. Schelter, S. Schaten, J.T. Siveke, N.H. Lim, H. Nagase, N. Simonavicius, M. Heikenwalder, T. Reinheckel, J.P. Sleeman, K.P. Janssen, P. Knolle, A. Krüger. TIMP-1 creates a pre-metastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice. Hepatology 61 : 238-248, 2015. doi: 10.1002/hep.27378

Cui, H., B. Seubert, E. Stahl, H. Dietz, U. Reuning, L. Moreno-Leon, M. Ilie, H. Nagase, B. Mari, A. Krüger. Tissue inhibitor of metalloproteinases-1 induces a pro-tumorigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes. Oncogene 34 : 3640-3650, 2015. doi: 10.1038/onc.2014.300

Kopitz, C., M. Gerg, O.R. Bandapalli, D. Ister, C.J. Pennington, S. Hauser, C. Flechsig, H.W. Krell, D. Antolovic, K. Brew, H. Nagase, M. Stangl, C.W. Hann von Weyhern, B.L. Brücher, K. Brand, L.M. Coussens, D.R. Edwards, A. Krüger. Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor-signaling. Cancer Res 67 : 8615-8623, 2007 doi: 10.1158/0008-5472.CAN-07-0232

Krüger, A., R. Soeltl, I. Sopov, C. Kopitz, M. Arlt, V. Magdolen, N. Harbeck, B. Gänsbacher, M. Schmitt. Hydroxamate-type matrix metalloproteinase inhibitor batimastat promotes liver metastasis. Cancer Res 61 : 1272-1275, 2001