Institut für Molekulare Immunologie
TUM School of Medicine and Health
Technical University of Munich
Systems Immunology

Our research focuses on using a system-level approach to integrate and analyze the high-dimensional datasets to understand the virus interactions with liver and brain cancer molecular mechanisms. We use a variety of various Omics (RNA-seq, single-cell RNA-seq) and combine them with a network-level approach and small molecule screening to illuminate the molecular-level events of genomic regulation in virus interactions and cancer and interrogate the therapeutic targets.

Dr. Sainitin Donakonda
Research Group Leader
Institut für Molekulare Immunologie
Ismaninger Straße 22
81675 München
Contact:
Team
Dr. Sainitin Donakonda
Dr. Sainitin Donakonda
E-Mail +49 89 4140 4453
NJ Manju NJ
NJ Manju NJ
E-Mail
Publications

2023

  1. Characterization of tumor microenvironment in glioblastoma multiforme identifies ITGB2 as a key immune and stromal related regulator in glial cell types Sai Krishna AVS, Alagammai Ramu, Srimathangi Hariharan, Swati Sinha and Sainitin Donakonda. Comput Biol Med, 2023, Aug 30: 165: 107433. https://www.sciencedirect.com/science/article/abs/pii/S0010482523008983?via%3Dihub
  2. Felix Bayerl, Philippa Meiser, Sainitin Donakonda, Anna Hirschberger, Sebastian B Lacher, Anna-Marie Pedde, Chris D Hermann, Anais Elewaut, Moritz knolle, Lukas Ramsauer, Thomas J Rudolph, Simon Grassmann, Ruper Öllinger, Nicole Kirchhammer, Marcel Trefny, Martina Anton, Dirk Wohlleber, Bastian Höchst, Anne Zaremba, Achim Krüger, Roland Rad, Anna C Obenauf, Dirk Schadendorf, Alfred Zippelius, Veit R Buchholz, Barbara U Schraml, Jan P Böttcher. Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses. Immunity, 2023, Jun 13; 56 (6): 1341-1358. https://www.cell.com/immunity/fulltext/S1074-7613(23)00228-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761323002285%3Fshowall%3Dtrue

2022

  1. AVS SK, Sinha S,  Donakonda S. Virus-host interaction analysis in colorectal cancer identifies core virus network signature and small molecules. Comput Struct Biotechnol J. 2022, Jul 28;20:4025-4039. https://www.sciencedirect.com/science/article/pii/S2001037022003208?via%3Dihub
  2. Michael Dudek*, Kerstin Lohr*, Sainitin Donakonda, Tobias Baumann, Max Lüdemann, Silke Hegenbarth, Lena Dübbel, Carola Eberhagen, Savvoula Michailidou, Abdallah Yassin, Marco Prinz, Bastian Popper, Stefan Rose-John, Hans Zischka, Percy A. Knolle. IL-6 induced FOXO1 activity determines the dynamics of metabolism in CD8 Tcells cross-primed by liver sinusoidal endothelial cells. *Equally contributed Cell Rep. 2022 Feb 15:38(7):110389. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00110-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124722001103%3Fshowall%3Dtrue
  3. Max Leudemann*, Daniela Stadler*, Cho-Chin Cheng, Ulrike Protzer, Percy A. Knolle, and Sainitin Donakonda. Montelukast is a dual-purpose inhibitor of SARS-CoV-2 infection and virus-induced IL-6 expression identified by structure-based drug repurposing. *equally contributed, Comput Struct Biotechnol J. 2022, Jan 29;20:799-811. https://www.csbj.org/article/S2001-0370(22)00031-9/fulltext

2021

  1. Samreen Fathima, Swati Sinha, Sainitin Donakonda. Unraveling Unique and Common Cell Type-Specific Mechanisms in Glioblastoma Multiforme. Comput Struct Biotechnol J. 2021 Dec9; 20:90-106. https://www.csbj.org/article/S2001-0370(21)00518-3/fulltext
  2. Adam Wahida*, Madeleine Müller*, Andreas Hiergeist, Bastian Popper, Katja Steiger, Caterina Branca, Markus Tschurtschenthaler, Thomas Engleitner, Sainitin Donakonda, Jordy De Coninck, Rupert Öllinger, Marie Pfautsch, Nicole Müller, Miguel Silva, Sinem Usluer, Jan P. Böttcher, Nicole Pfarr, Martina Anton, Julia B. Slotta-Huspenina, Andreas G. Nerlich, Tobias Madl, Geert Berx, Jürgen Ruland, Percy A. Knolle, Roland Rad, Timon E. Adolph, Peter Vandenabeele, Hirokazu Kanegane, André Gessner, Philipp J. Jost, Monica Yabal. Aberrant TNF Signaling Links RIPK3-Dependent Cell Death and Loss of TLR5 with Intestinal Inflammation and Dysbiosis. *equally contributed, Science Immunol, 2021 Nov 5; 6(65). https://www.science.org/doi/10.1126/sciimmunol.abf7235
  3. Suliman Qadir Afridi, Zainab Usman, Sainitin Donakonda, Jochen Martin Wettengel, Stoyan Velkov, Robert Beck, Markus Gerhard, Percy Knolle, Ulrike Protzer, Hassan Moeini, Dieter Hoffmann. Prolonged NoV infections correlate to quasispecies evolution resulting in structural changes of surface-exposed epitopes.iScience. 2021 Jun 30;24(7):102802. https://www.cell.com/iscience/fulltext/S2589-0042(21)00770-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004221007707%3Fshowall%3Dtrue
  4. Anna Kurz*, Rohit Kumar*, Bernd H. Northoff, Catharina Wenk, Jörg Schirra, Sainitin Donakonda, Günter U. Höglinger, Johannaes Schwarz, Verena Rozanski, Rainer Hübner, Kai Bötzel, Lesca Holdt, Thomas Koeglsperger. Differential expression of gut miRNAs in idiopathic Parkinson’s disease.  *equally contributed Parkinsonism and Relat Disord. 2021, Jul 21,88:46-50. https://www.prd-journal.com/article/S1353-8020(21)00193-0/fulltext
  5. Nithishwer Mouroug Anand, Devang Haresh Liya, Arpit kumar Pradhan, Nitish Tayal, Abhinav Bansal, Sainitin Donakonda, Ashwin K. Jainarayanan. A comprehensive SARS-CoV-2 genomic analysis identifies potential targets for drug repurposing. PlosOne. 2021, Mar 18,16(3):e0248553. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0248553
  6. Samreen Fathima, Swati Sinha$ and Sainitin Donakonda$. Network analysis identifies drug targets and small molecules to modulate apoptosis resistant cancers. $Co-Corresponding authors, MDPI cancers. 2021, Feb 18;13(4):851.https://www.mdpi.com/2072-6694/13/4/851
  7. Michael Dudek, Dominik Pfister, Sainitin Donakonda, Pamela Filpe, Annika Schneider, Melanie Laschinger, Daniel Hartmann, Norbert Hüser, Philippa Meiser, Felix Bayerl, Donato Inverso, Jennifer Wigger, Marcial Sebode, Rupert Öllinger, Roland Rad, Silke Hegenbarth, Martina Anton, Adrien Guillot, Andrew Bowman, Danijela Heide, Florian Müller, Pierluigi, Ramadori, Valentina Leone, Cristina Garcia-Caceres, Tim Gruber, Gabriel Seifert, Agnieszka M. Kabat, Jan-Philipp, Malm, Simon Reider, Maria Effenberger, Susanne Roth, Adrian Billeter, Beat Müller-Stich, Edward J. Pearce, Friedrich Koch-Nolte, Rafael Käser, Herbert Tilg, Robert Thimme, Tobias Böttler, Frank Tacke, Jean-Francois Dufou,  Dirk Haller, Peter J. Murray, Ron Heeren, Dietmar Zehn, Jan P. Böttcher, Mathias Heikenwälder, Percy A. Knolle. Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH.https://www.nature.com/articles/s41586-021-03233-8
  8. Hassan Moeini, Suliman Qadir Afridi*, Sainitin Donakonda*, Percy Knolle, Ulrike Protzer, Dieter Hoffmann. Linear Blockade B-cell Epitopes in Human Norovirus GII.4 Capsid Protein Elicit Blockade Antibodies. * equally contributed - Joint second author,  MDPI Vaccines 2021 Jan 14; 9(1):E52. https://www.mdpi.com/2076-393X/9/1/52

2020

  1. Rohit kumar*, Sainitin Donakonda*, Stephan A. Müller, Kai   Bötzel,   Günter U.     Höglinger, Thomas Koeglsperger. FGF2 affects  Parkinson’s disease-associated molecular networks through Rab8b/Rab31. * equally contributed, Front Genet. 2020 Sep 25;11:572058. https://www.frontiersin.org/articles/10.3389/fgene.2020.572058/full
  2. Rohit Kumar*, Sainitin Donakonda*, Stephan A.Müller, Stefan F.Lictenthaler, Kai Bötzel, Günter Höglinger, Thomas Kögelsperger. Basic fibroblast growth factor 2-induced proteome changes endorse lewy body pathology in hippocampal neurons. *Equally contributed  iScience. 2020 Aug 21;23(8):101349. https://www.cell.com/iscience/fulltext/S2589-0042(20)30536-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004220305368%3Fshowall%3Dtrue
  3. Sandra Lampl§, Marianne K. Janas§, Sainitin Donakonda§, Marcus Brugger, Kerstin Lohr1, Annika Schneider, Katrin Manske, Laura E. Sperl, Jennifer Wettmarshausen, Constanze Müller, Fabiana Perrochi, Philippe Schmitt-Kopplin, Franz Hagn, Lars Zender, Veit Hornung, Christoph Borner, Andreas Pichlmair, Hamid Kashkar, Martin Klingenspor, Marco Prinz, Sabrina Schreiner, Marcus Conrad, Philipp J. Jost, Hans Zischka, Katja Steiger, Martin Krönke, Dietmar Zehn, Ulrike Protzer, Mathias Heikenwälder,  Percy A. Knolle§ & Dirk Wohlleber§. Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes. Equally contributed. J hepatology 2020, Dec;73(6):1347-1359.https://www.journal-of-hepatology.eu/article/S0168-8278(20)30398-6/fulltext

2019

  1. Tobias Baumann, Andreas Dunkel , Christian Schmid, Sabine Schmitt, Michael Hiltensperger , Kerstin Lohr, Vibor Laketa , Sainitin Donakonda, Uwe Ahting, Bettina Lorenz-Depiereux,Jan E. Heil, Johann Schredelseker , Luca Simeoni, Caroline Fecher , Nina Körber ,Tanja Bauer, Norbert Hüser, Daniel Hartmann, Melanie Laschinger, Kilian Eyerich, Stefanie Eyerich, Martina Anton, Matthew Streeter, Tina Wang, Burkhart Schraven,David Spiegel, Farhah Assaad, Thomas Misgeld, Hans Zischka, Peter J. Murray,Annkristin Heine, Mathias Heikenwälder, Thomas Korn , Corinna Dawid, Thomas Hofmann, Percy A. Knolle and Bastian Höchst. Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal. Nat Immunol. 2020 May;21(5):555-566. https://www.nature.com/articles/s41590-020-0666-9
  2. Julia Matthias, Julia Maul, Rebecca Noster, Hanna Meinl, Ying-Yin Chao, Heiko Gerstenberg, Florian Jeschke, Gilles Gasparoni, Anna Welle, Jörn Walter, Karl Nordström, Klaus Eberhardt, Dennis Renisch, Sainitin Donakonda, Percy Knolle, Dominik Soll, Stephan Grabbe, Natalie Garzorz-Stark, Kilian Eyerich, Tilo Biedermann, Dirk Baumjohann, Christina E. Zielinski. Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment. Sci Transl Med. 2019 Feb 20:11(480). https://www.science.org/doi/10.1126/scitranslmed.aau0683

2017

  1. Sainitin Donakonda, Swati Sinha, Shrinivas Nivrutti Dighe, Rao MRS. Systems analysis identifies distinct and common functional networks governed by transcription factor ASCL1 in glioma and small cell lung cancer. Mol Biosyst. 2017 Jul 25;13(8):1481-1494. https://pubs.rsc.org/en/content/articlelanding/2017/MB/C6MB00851H

2016

  1. Joerg-Christian Heincrich*, Sainitin Donakonda*, Joachim Haupt*, Petra Lenning, Yixin Zhang and Michael Schroeder. New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells. * equally contributed, Oncotarget 2016 Oct 18;7(42):681560-68169.

2014

  1. Vijay Akhade, Gayatri ganesan, Sainitin Donakonda and Satyanarayana Rao MR. Genome wide chromatin occupancy of mrhl RNA and its role in gene regulation in mouse spermatogonial cells. https://www.tandfonline.com/doi/full/10.1080/15476286.2014.996070

2013

  1. Swati Sinha, Sainitin Donakonda, Rao MRS. Analysis of in vivo occupancy of Aebp1, a transcription factor, using high resolution tiling array. Methods Mol Biol. 2013. 1067:165-183. https://link.springer.com/protocol/10.1007/978-1-62703-607-8_11

2012

  1. Gayatri ganesan*, Vijay Akhade*, Sainitin Donakonda and Rao MRS.              mrhl   RNA, a Long Noncoding RNA, Negatively Regulates Wnt Signaling through Its Protein Partner Ddx5/p68 in Mouse Spermatogonial Cells. *Equally Contributed Mol Cell Biol. 2012 Aug;32(15):3140-3152. https://www.tandfonline.com/doi/abs/10.1128/MCB.00006-12?journalCode=tmcb20
  2. Jayashree Ladha*, Swati Sinha*, Vasudev Bhat$, Sainitin Donakonda$, and Satyanarayna M.R, Rao. Identification of genomic targets of transcription factor AEBP1 and its role in survival of glioma cells. (*Joint first authors $Joint second authors), Mol Cancer Res. 2012 Aug;10(8):1039-1051. https://aacrjournals.org/mcr/article/10/8/1039/89279/Identification-of-Genomic-Targets-of-Transcription

2010

  1. Jayashree Ladha, Sainitin Donakonda, Shipra Agrawal, Balaram Thota, Srividya, Sridevi, Arizhagan, Thennarasu, Anandh Balasubramaniam, Chandramouli, Hegde, Paturu Kondaiah, Kumaravel Somasundaram, Vani Santhosh and Satyanarayna M.R, Rao. Glioblastoma specific protein interaction network identifies PP1A and CSK21 as connecting molecules between cell cycle associated genes. Cancer Res. 2010 Aug 15. 70(16):6437-6447.https://aacrjournals.org/cancerres/article/70/16/6437/559465/Glioblastoma-Specific-Protein-Interaction-Network

 

PATENT

Thymine derivatives and quinazoline-dione derivatives for the inhibition of hsp27 (US patent application no: US20180207160A1). Granted on 09.03.2021.

 

The full list of our publications can be found on Pubmed. 

Funding

We are supported by institutional funds.